Trend and predictors for early infant diagnosis by PCR among HIV-exposed infants in Dar es Salaam region, Tanzania, 2014-2016

MICHAEL F. MBOYA (1) , PROSPER NJAU (2) , JIM TODD (3) , BEATRICE JOHN LERAYO (4) , GOODLUCK WILEY LYATUU (5) , LAMECK MACHUMI (6) , SIA E. MSUYA (7) , MICHAEL J. MAHANDE (8) , JENNY RENJU (9)
(1) Kilimanjaro Christian Medical University College, Moshi, Tanzania , Tanzania, United Republic of
(2) Kilimanjaro Christian Medical University College, Moshi, Tanzania , Tanzania, United Republic of
(3) London School of Hygiene & Tropical Medicine, London, UK , United Kingdom
(4) Kilimanjaro Christian Medical University College, Moshi, Tanzania , Tanzania, United Republic of
(5) Management and Development for Health, Dar Es Salaam, Tanzania , Tanzania, United Republic of
(6) Management and Development for Health, Dar Es Salaam, Tanzania , Tanzania, United Republic of
(7) Kilimanjaro Christian Medical University College, Moshi, Tanzania , Tanzania, United Republic of
(8) Kilimanjaro Christian Medical University College, Moshi, Tanzania , Tanzania, United Republic of
(9) London School of Hygiene & Tropical Medicine, London, UK , United States

Abstract

BACKGROUND


Early infant diagnosis (EID) of HIV and timely initiation of antiretroviral therapy reduces morbidity and mortality in HIV-infected infants and children. Although the WHO had a global target for 2018 that 90% of HIV-exposed infants (HEI) should be tested by the age of 8 weeks, by 2015 only half were being tested. This study describes trends and predictors for HIV first testing in HEI in Dar es Salaam, Tanzania, from 2014 to 2016.


 METHODS


We conducted a cross-sectional study of HEI attending HIV services using secondary data collected at health facilities and collated at the national level. We estimated odds ratios and 95% confidence intervals for factors affecting uptake of HIV testing.


 RESULTS


Of 12,117 HEI, the proportion tested for HIV by age 8 weeks increased from 53.2% in 2014 to 69.2% in 2016; 2.3% were HIV-positive. Replacement feeding (aOR=2.94, 95% CI 2.31 – 3.74) and receiving nevirapine prophylaxis (aOR=1.55, 95% CI 1.28-1.88) were predictors for EID testing uptake. HEI born to mothers with WHO stage II (aOR=0.53, 95% CI 0.41 – 0.67), stage III (aOR=0.64, 95% CI; 0.52 – 0.79) and stage IV (aOR=0.58, 95% CI 0.34 – 0.99) were less likely to be tested than those born to mothers with WHO stage I disease progression.


 CONCLUSION


There was an increasing trend in the uptake of HIV testing of infants at age 8 weeks during the study period. However, it is still below the global target. Efforts to promote EID testing are still needed.

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Authors

MICHAEL F. MBOYA
Michaelf600@gmail.com (Primary Contact)
PROSPER NJAU
JIM TODD
BEATRICE JOHN LERAYO
GOODLUCK WILEY LYATUU
LAMECK MACHUMI
SIA E. MSUYA
MICHAEL J. MAHANDE
JENNY RENJU
Author Biographies

MICHAEL F. MBOYA, Kilimanjaro Christian Medical University College, Moshi, Tanzania

Department of Epidemiology & Biostatistics, Institute of Public Health

PROSPER NJAU, Kilimanjaro Christian Medical University College, Moshi, Tanzania

Department of Epidemiology & Biostatistics, Institute of Public Health

JIM TODD, London School of Hygiene & Tropical Medicine, London, UK

Department of Population Health

BEATRICE JOHN LERAYO, Kilimanjaro Christian Medical University College, Moshi, Tanzania

Department of Epidemiology & Biostatistics, Institute of Public Health

SIA E. MSUYA, Kilimanjaro Christian Medical University College, Moshi, Tanzania

Department of Epidemiology & Biostatistics, Institute of Public Health

MICHAEL J. MAHANDE, Kilimanjaro Christian Medical University College, Moshi, Tanzania

Department of Epidemiology & Biostatistics, Institute of Public Health

JENNY RENJU, London School of Hygiene & Tropical Medicine, London, UK

Department of Population Health,

MBOYA, M. F. ., NJAU, P., TODD, J., LERAYO, B. J., LYATUU, G. W., MACHUMI, L., MSUYA, S. E., MAHANDE, M. J., & RENJU, J. (2020). Trend and predictors for early infant diagnosis by PCR among HIV-exposed infants in Dar es Salaam region, Tanzania, 2014-2016. Eajahme, 4(4). https://doi.org/10.58498/eajahme.v4i4.26
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